Preparation method for tenofovir disoproxil fumarate (TDF)

The invention provides a novel preparation method for tenofovir disoproxil fumarate (TDF). The TDF is obtained by conducting esterifying and salifying refining on TDF-SM which is used as a raw material. The preparation method for the TDF has the characteristics that the reaction condition is mild, production cost is low, quality is good, and industrialized production is convenient.