Research progress of long non-coding RNAs in thyroid cancer

Thyroid cancer is an endocrine tumor with a rapid increase in prevalence in recent years. Human malignant tumors are closely related to environmental factors. Environmental changes can induce changes in certain pathogenic genes in the body, thus promoting the occurrence of diseases. A class of non-coding RNAs over 200 nucleotides in length, known as long non-coding RNAs(LncRNAs), has been found in human transcriptomes. LncRNAs are non-coding RNAs over 200 nucleotides in length that are involved in tumorigenesis, cell proliferation, proliferation, apoptosis, migration, and invasion by regulating gene expression. More and more studies have found that LncRNAs are closely related to thyroid cancer. Many LncRNAs have carcinogenic or tumor suppressive effects on the thyroid gland, but its function and mechanism are still unclear. This article reviews the recent research progress of LncRNAs in thyroid cancer, and provides a basis for exploring the mechanism of LncRNAs in thyroid cancer and its clinical application. Key words: RNA, long noncoding; Thyroid neoplasms; Biomarkers; Diagnosis; Prognosis