Intrinsic versus laser-induced fluorescence spectroscopy for coronary atherosclerosis: A generational comparison model for testing diagnostic accuracy
2012
Laser-induced fluorescence (LIF) and intrinsic fluorescence spectroscopy (IFS)
have been used experimentally for diagnosing coronary atherosclerosis. In this
study, we demonstrated the diagnostic superiority of IFS at 342-nm excitation
(IFS342) versus LIF (LIF342) and described a protocol for
head-to-head comparison of old (LIF) versus new (IFS) generations of similar
diagnostic methods, labeled as “generational comparison model”. IFS342
and LIF342 were modeled with basis spectra of media, fibrous caps, and
superficial foam cells and of their correspondent chemicals (elastin, collagen, and
lipoproteins). The average accuracy and receiver operating characteristic area under
the curve of IFS342 in single-, double-, and triple-parameter diagnostic
algorithm iterations, geared toward identifying 84 atherosclerotic specimens from a
group of 117 coronary segments, was 90% ± 1% and 0.87 ± 0.025, superior to
LIF342 (84% ± 3% and 0.84 ± 0.016; P = 0.0002 and 0.02,
respectively) in a generational comparison model.
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