Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3.

M. Hirschi,Mark A. Herzik,Jinhong Wie,Yang Suo,William F. Borschel,Dejian Ren,Gabriel C. Lander,Seok-Yong Lee

Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3.

2017

M. Hirschi
Mark A. Herzik
Jinhong Wie
Yang Suo
William F. Borschel
Dejian Ren
Gabriel C. Lander
Seok-Yong Lee

A cryo-electron microscopy structure shows that the mucolipin domain of the lysosomal calcium channel TRPML3 binds phosphatidylinositol-3,5-bisphosphate and gates the channel.

Keywords:

TRPML
Cryo-electron microscopy
Transient receptor potential channel
Calcium
Microscopy
Calcium channel
Protein domain
Cell biology
Ion transporter
Biology
MCOLN1
Mucolipidosis type IV
Calcium signaling
Ion channel

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