Diagnosis of Diffuse Large B-Cell Lymphoma

Diffuse large B-cell lymphoma (DLBCL), the most common type of non-Hodgkin lymphoma (NHL), is a heterogeneous group of B-cell lymphomas with several distinctive subsets. Most of lymphoma cases in developing and tropical countries are aggressive lymphomas comprising Burkitt lymphoma and DLBCL. As several entities belong to the DLBCL category identified by the WHO classification, the identification of DLBCL is important for the diagnosis and the treatment. In low- and medium-income countries, the development of molecular and genetic techniques is still insufficient for an accurate diagnosis. However, diligent application of morphology and usage of a limited panel of immunohistochemistry and an algorithmic approach allow the identification of most subcategories and clinicopathologic entities of DLBCL.