Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism
2010
The bacterial protease ClpP forms an active complex with Clp-ATPases, but can also be directly activated by a recently characterized class of antibiotics (ADEP). Now the crystal structures of Bacillus subtilis ClpP bound to ADEPs reveal the conformational changes involved in ClpP's activation.
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