Kinetic, Mechanistic and Thermodynamic aspects of Lidocaine Oxidation by Chloramine-T in Perchloric Acid medium

The kinetics of lidocaine hydrochloride (LC) oxidation by sodium N-chloro p-toluenesulfonamide (CAT) in perchloric acid medium has been studied at 303K. The reaction stoichiometry was determined and oxidation products were identified. The reaction rate shows a first order dependence on [CAT] and fractional order on [LC] whereas inverse fractional order on [H + ]. The products of reaction have no considerable effect on the rate. There is a slight negative effect by the dielectric constant. The rate remains same with the variation in the ionic strength of the medium indicating the involvement of non ionic species in rate determining step. There were no free radicals during the course of reaction. Kinetic runs were performed at different temperatures and thermodynamic parameters were computed. A mechanism consistent with observed parameters is proposed and rate law is derived.