Nucleotide-induced global conformational changes of flagellar dynein arms revealed by in situ analysis

Eukaryotic flagella and cilia contain at their core microtubules that slide against each other to produce a bending motion. The movement is powered by dynein molecules associated to the microtubules. Now an in situ cryo-electron tomography analysis of Chlamydomonas reinhardtii flagella reveals the global conformational changes induced by nucleotides in the outer and inner dynein arms.