Possible Therapeutic Potential of Flavonoids and Phenolic Acids from Honey in Age-Related Neurodegenerative Diseases Via Targeting NAD+ Degradation

Neurodegenerative disorder is the major age-related problem with no specific cure. The drugs available in the market relieve the severity of the disease and increase the average life span. There is always room for more novel therapeutic strategies for the prevention of neurodegenerative diseases. Honey has been used since ages for various disease prevention, and recently it has been used to combat these diseases too. The flavonoids and the phenolic acids of honey have preventive effects and have been known to exhibit antioxidant, anti-inflammatory, and anti-apoptotic effects. These phytochemicals can prevent the neurodegeneration via NAD pathway where they are responsible for inhibiting CD38, PARP and activating SIRT1 overall by increasing the concentration of NAD in the neurons. With an increase in the amount of NAD, Sirtuins can be activated which protects age-related neurodegenerative diseases. Therefore, honey can be used as “NAD compounds” in clinics but with further mechanistic research.