Derivatives of 4- (2-fenilsufanil-phenyl) -piperidine as inhibitors of serotonin reuptake.

2004 
A compound represented by the general formula I (See formula) wherein R 1, R 2, R 3, R 4, R 5 are independently hydrogen, halogen, cyano, alk (en / yn) yl-C1 selected - 6 alk (en / yn) yloxy-C1 - 6 alk (en / yn) yl-C1 - 6sulfanilo, hydroxy, hydroxy-alk (en / yn) yl-C1 - 6, halo-alk (en / yn) yl -C1 - 6, halo-alk (en / yn) yloxy-C1 - 6 or NR x R y wherein R x and R and are independently selected from hydrogen, alk (en / yn) yl-C1 - 6, cyano- alk (en / yn) yl-C1 - 6, cycloalk (en) yl-C 3 - 8 -cycloalk (en) yl-C 3 - 8-alk (en / yn) yl-C1 - 6 or NR z R w -alqu (en / yn) yl-C1 - 6, wherein R z and R w are independently selected from hydrogen, alk (en / yn) yl-C1 - 6, cycloalk (en) yl-C 3 - 8 or cycloalk ( en) yl-C 3 - 8-alk (en / yn) yl-C1 - 6; or R x and R and together with the nitrogen to which they are attached form a 3-7 membered ring optionally containing another heteroatom; R 6, R 7, R 8, R 9 are independently selected from hydrogen, halogen, alk (en / yn) yl-C1 - 6 alk (en / yn) yloxy-C1 - 6 alk (en / yn) yl -C1 - 6sulfanilo, hydroxy, hydroxy-alk (en / yn) yl-C1 - 6, halo-alk (en / yn) yl-C1 - 6, halo-alk (en / yn) yloxy-C1 - 6 or NR x R y wherein R x and R and are independently selected from hydrogen, alk (en / yn) yl-C1 - 6, cyano-alk (en / yn) yl-C1 - 6, cycloalk (en) yl-C3 - 8-cycloalk (en) yl-C 3 - 8-alk (en / yn) yl-C1 - 6 or NR z R w -alqu (en / yn) yl-C1 - 6, wherein R z and R w are selected independently hydrogen, alk (en / yn) yl-C1 - 6, cycloalk (en) yl-C 3 - 8 -cycloalk (en) yl-C 3 - 8-alk (en / yn) yl-C1 - 6; or R x and R and together with the nitrogen to which they are attached form a 3-7 membered ring optionally containing another heteroatom; with the proviso that at least one of R 1, R 2, R 3, R 4, R 5, R 6, R 7, R 8 and R 9 is different from hydrogen; also with the proviso that when R 3 is methyl, at least one of R 1, R 2, R 4, R 5, R 6, R 7, R 8, R 9 is different from hydrogen; or a salt thereof.
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