Synthesis and Crystal Structure Studies of a Novel Bioactive Heterocycle: 1-Benzhydryl-4-phenylmethane Sulfonyl Piperazine

Benzhydryl-4-phenylmethane sulfonyl piper- azine was synthesized from 1-benzhydryl piperazine with phenylmethane sulfonyl chloride. The product obtained was characterized by 1 H NMR, MS and IR techniques and finally confirmed by X-ray crystallography. The title compound C24H26N2O2S, Mr = 406.53, crystallizes in the ortho- rhombic crystal class in the space group Pbca with unit cell parameters a = 11.1240(10)A ˚ , b = 9.4940(15)A ˚ , c = 40.239(4)A ˚ , Z = 8 and V = 4249.7(9)A ˚ 3 . The struc- ture was solved by direct methods and refined to R1=0.0561 for 2,445 reflections with (I ( 2 r(I)). The piperazine ring adopts a chair conformation. The sulfonyl moiety is in a distorted tetrahedral configuration.