Rapid incorporation of difluoroacetate radical into para-quinone methides via radical 1,6-conjugate addition

Presented herein is a newly designed strategy which rapidly introduces ethyl difluoroacetate radicals through a dialkylzincs induced radical 1,6-conjugate addition pathway. Besides achieving high yields and excellent functional groups compatibility, this protocol allowed the incorporation of gem-difluoromethylene motif to be accomplished within minutes.