N-Alkoxymethylation of Carboxamides Catalyzed by Brønsted Acids

The reaction of carboxamides and dialkoxymethanes can be affected by sulfonic acids (methanesulfonic acid, p-toluene-sulfonic acid, and Nafion-H SAC-13 silica nanocomposite) to yield N-alkoxymethylcarboxamides. Various types of N-alkyl- and N-aryl-substituted acetamides can be reacted in a one-step procedure to give the products in moderate to good yields.