Comparison of Rupture Test and Disintegration Test on Soft Capsules

Objective To compare the rupture test of soft capsules of dietary supplements with the disintegration test,and to find the correlations and differences.Methods The rupture time and disintegration time of soft capsules were tested by the method in USP 32 and CHP 2005.The results were analyzed.Results There are some correlations and differences between rupture and disintegration of soft capsules.Conclusion The soft capsules of dietary supplements that comply with the disintegration test should go through the rupture test according to the USP when exported,the rupture test could not be replaced by disintegration test.