Inhibition of two Cu(II) and Mn(II) coordination polymers on the surgical site infections by inhibiting the bacterial biofilm formation

Abstract Within this work, two novel Cu(II) and Mn(II)-based coordination polymers (CPs) along with chemical compositions of {[Cu2(L1)(1,4-NDC)2]·3H2O}n (1, 1,4-H2NDC = Naphthalene-1,4-dicarboxylic acid, L1 ​= ​di(1H-imidazole-1-yl)methane) and [Mn3(L2)2(H2O)2(1,4-NDC)2]n (2, L2 ​= ​1,4-di(1H-imidazole-1-yl)benzene) have been completed in success via related metal salts reaction with 1,4-H2NDC ligand in existence of various N-donor co-ligands. We discovered its application values on the surgical site infections (SSI) along with corresponding mechanism in the interim. We evaluated inflammatory cytokines released into the urine through ELISA detection kit after compound treatment. Then, we discovered the inhibitory effect of compound on the bacterial biofilm formation via real time RT-PCR.