Protein structure determination by combining sparse NMR data with evolutionary couplings

Y. Tang,Yuanpeng Janet Huang,Thomas A. Hopf,Chris Sander,Debora S. Marks,Gaetano T. Montelione

Protein structure determination by combining sparse NMR data with evolutionary couplings

2015

Y. Tang
Yuanpeng Janet Huang
Thomas A. Hopf
Chris Sander
Debora S. Marks
Gaetano T. Montelione

A hybrid method that combines sparse NMR spectroscopy data with evolutionary residue-residue coupling information is used to solve accurate structures of large proteins.

Keywords:

Protein structure
Nuclear magnetic resonance spectroscopy
Bioinformatics
Structural genomics
Biology
Coupling
Proto-Oncogene Proteins
nmr data
signaling proteins
molecular conformation

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