Antifungal activity of sterols and triterpenes isolated from Ganoderma annulare

Three sterols, 5α-ergost-7-en-3β-ol, 5α-ergosta-7,22-dien-3β-ol and 5,8-epidioxy-5α,8α-ergosta-6,22-dien-3β-ol and five triterpenes, applanoxidic acids A, C, F, G and H, have been isolated from Ganoderma annulare. The applanoxidic acids A, C and F were found to inhibit the growth of the fungi Microsporum cannis and Trichophyton mentagrophytes at concentrations of 500 to 1000 μg/ml.