Catalytic Enantioselective Thioester Aldol Reactions That Are Compatible with Protic Functional Groups

Derek Magdziak,Gojko Lalic,Hong Myung Lee,Kevin C. Fortner,and Allen D. Aloise,Matthew D. Shair

Catalytic Enantioselective Thioester Aldol Reactions That Are Compatible with Protic Functional Groups

2005

Derek Magdziak
Gojko Lalic
Hong Myung Lee
Kevin C. Fortner
and Allen D. Aloise
Matthew D. Shair

This communication reports highly enantioselective and diastereoselective methyl malonic acid half thioester (MeMAHT) aldol reactions that are compatible with protic functional groups and enolizable aldehydes, affording syn S-phenyl thiopropionates.

Keywords:

Aldol condensation
Enantioselective synthesis
Catalysis
Organic chemistry
Thioester
Aldol reaction
Chemistry
Methyl malonic acid

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