Evolution of a Preparation Route to Sulfamoylamino Intermediates of Cephalosporin

Development of a convergent preparation route to sulfamoylamino intermediates of cephalosporin is described.The target molecule is assembled through an azabicyclo [2.2.1] heptane intermediate followed by condensation reaction with sulfamoylamino methylpiperidine derivatives. The preparation of azabicyclo [2.2.1] heptane intermediate by a intramolecular condensation reaction of (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid. This avoids handling of column chromatography and l improves the overall yield and efficiency of the route.