From elastin peptides to neuraminidase-1-dependent lactosylceramide generation

Abstract Elastin peptides constitute a group of biologically active peptides derived from the fragmentation of insoluble elastin. These molecules, currently termed elastokines, have been shown to interact preferably with the elastin receptor complex. Recent data show that the sialidase activity of the neuraminidase-1 of this receptor is required for these peptides to induce their effects. As lactosylceramide generated at the plasma membrane by desialylation of the ganglioside GM 3 can be considered as a second messenger, we feel that this lipidic compound could mimic elastin peptides effects in physiopathological situations.