Prediction of the secondary structure and B cell epitopes on major cat allergen Fel d 1
2011
Objective To predict and analyze the secondary structure and B cell epitopes of cat major allergen Fel d 1.Methods Based on the amino acid sequence of chain Ⅰ and chain Ⅱ of Fel d 1.the secondary structure,hydrophilicity,flexible regions,surface probability,and antigenic index were predicted by the methods of Chou-Fasman,Kyte-Doolittle,Karplus-Schulz,Emini and Jameson-Wolf respectively,and DNAStar Protean software,Rtault The potential B cell epitopes of Fel d 1 were localized in the regions of 15~21,48~57,103-111,138~143,and 151~161.Conclusion These findings are helpful for the identification of the dominant B cell epitopes.The results can provide the antibodies design and antigenieity modification of Fel d 1 with theoretical foundation.
Key words:
Cat major allergen; Fel d 1; Secondary structure; B cell epitopes
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