Proposed Mathematical Model for Calibration of Potential Detection of Nonlinear Responses in Biological Media Exposed to RF Energy

An efficient way to test for potential unsymmetrical nonlinear responses in biological tissue samples exposed to a microwave signal is to observe the second harmonic in a cavity resonant at the two frequencies, with collocated antinodes. Such a response would be of interest as being a mechanism that could enable demodulation of information-carrying waveforms. In this work, an electric circuit model is proposed to facilitate calibration of any putative nonlinear RF energy conversion inside a high quality-factor resonant cavity with a known nonlinear loading device. The first and second harmonic responses of the cavity due to loading with the nonlinear and lossy material are also demonstrated. The results from the proposed mathematical model give a good indication of the input power required to detect any very weak second harmonic signal in relation to the sensitivity of the measurement equipment. Hence, this proposed mathematical model will assist in determining the level of the second harmonic signal in the detector as a function of the specific input power applied.