UV-protective activities of pineapple leaf extract in zebrafish embryos

The UV-protective activities of pineapple leaf extract in a zebrafish model have been evaluated by recording fin morphological changes. UV protective effects of pineapple leaf extract was evaluated using Kaplan–Meier analysis and Cox proportional hazards regression. The results showed that (1) the mean time of return to normal fin in the UV + pineapple leaf extract (100 and 400 μg/mL) groups are 3.90 and 2.50 days, respectively, more quickly than in the UV only group (4.12 days); (2) zebrafish fins in the pineapple leaf extract (100 and 400 μg/mL) groups are 1.44 and 4.29 times, respectively, more likely to return to recover than those in the UV only group; and (3) pineapple leaf extract has UV-absorbance abilities and significantly reduces p53 expressions and ROS generation in UV-exposed zebrafish embryos, which may attenuate UV-mediated apoptosis.