Efficient transformation of 7,14-dihydroxy-ent-kaurenes to novel ent-abietanes having cis-fused α-methylene γ-lactones under Mitsunobu reaction conditions and their cytotoxicities

Abstract Transformation of plant-origin 7,14-dihydroxy- ent -kaurenes to ent -abietanes having a cis -fused α-methylene γ-lactones was accomplished efficiently under the Mitsunobu reaction conditions. The yields of the desired products were apparently influenced by the steric hindrance at C-1. The cytotoxic activity on P388 murine leukemia cells of the ent -abietanes having cis -fused α-methylene γ-lactones produced were assayed.