Single mode and sub-cellular fiber probes for cell scattering and density variation measurements
2012
Cell density is an important parameter in the question of bio-variation and the studying of cell scattering could
be a viable tool. The development of spatially resolved optical fiber probe would enable the characterization of
optical scattering from cells within a colony. Single mode fiber probe would be budget friendly as compared to a
50-nm sub-cellular fiber probe. This project develops a calibration procedure to correlate the optical scattering
measured by a single mode fiber probe to that of a 50-nm sub-cellular fiber probe in the context of cell density
variation. The Fourier transform of intensity angular transmission would give correlation information in the Efield
in the spatial coordinate. Monte Carlo simulation could be used to constrain the input intensity function
spatial content resembling microscopy. The use of a 50-nm sub-cellular fiber probe for detailed study of
biological samples would give sub-micron scale length information.
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