Phenotypic heterogeneity of neurological disorders associated with glutamic acid decarboxylase antibodies

Neurological disorders associated with glutamic acid decarboxylase (GAD65) antibodies represent a relatively new field of research in the modern clinical neurology and are of great theoretical and practical interest. High titer of anti-GAD65 antibodies is a highly sensitive, though not always specific, marker of the autoimmune disorders of the central nervous system (CNS). Literature review and authors' clinical observations of the phenotypic heterogeneity of GAD65-associated disorders are presented in the paper.