Lipophilicity and Click Reactivity Determine the Performance of Bioorthogonal Tetrazine Tools in Pretargeted In Vivo Chemistry

E. Johanna L. Stéen,Jesper Jørgensen,Christoph Denk,Umberto Maria Battisti,Kamilla Norregaard,Patricia E. Edem,Klas Bratteby,Vladimir Shalgunov,Martin Wilkovitsch,Dennis Svatunek,Christian B. M. Poulie,Lars Hvass,Marina Simón,Thomas Wanek,Raffaella Rossin,Marc S. Robillard,Jesper L. Kristensen,Hannes Mikula,Andreas Kjær,Matthias M. Herth

Lipophilicity and Click Reactivity Determine the Performance of Bioorthogonal Tetrazine Tools in Pretargeted In Vivo Chemistry

2021

The development of highly selective and fast biocompatible reactions for ligation and cleavage has paved the way for new diagnostic and therapeutic applications of pretargeted in vivo chemistry. Th...

Keywords:

Combinatorial chemistry
In vivo
highly selective
Bioorthogonal chemistry
Tetrazine
Molecular imaging
Biocompatible material
Chemistry
Lipophilicity

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