A Study of Mass Spectrometry of 2-Amino-5-substituted-4-thiazolyl Phosphonates

The fragmentation characteristic of a series of recently developed 2-amino-5-substituted-4-thiazolyl-phosphonates is studied by using electron impact (EI), electron impact-collision activity-mass analysed ion kinetic energy spectrometry (EI-CA-MIKES) and accurate mass measurment (AMM ) techniques. It is found that a new type of γ-alkyl rearrangement has occured as evidenced by the'pres-ence of a molecular daughter ion of ethylated thiazole ring(m/z 203). The molecular parent and daughter ions have been fully identified by their unsaturation , accurate ion mass and elementary constitution. The fragmentation pathway is portrayed in a scheme(see Fig. 2)