Bipolar Disorder Boon or a Curse A Comprehensive Review

The present paper provides a critical review of the evidence of ongoing clinical issues in bipolar disorder. However, the literature supports a strong association of smoking and alcohol dependence in bipolar disorder patients. Growing evidence suggests that higher suicidal ideation and higher risk for attempted suicides in individuals is associated with BPD. A family-based association study shows that first-degree relatives and monozygotic twins are probably more chances to affect with bipolar disorder. Specifically, brain structural abnormalities in limbic-cortical-striatal-pallidal-thalamic tract have been reported in patients with BPD. Creativity and realism are correlated with hypomania and depression. However, people with bipolar disorder are more creative when effectively treated than when they are not treated. Consistent with the depressive realism effect, depressed individuals are more realistic than the non- depressed. Here, we discussed the findings from clinical, epidemiological, neuroimaging and post- mortem studies, as well as the implication of the available data, identify current challenges impeding progress and define areas for future investigation.