Mesopontine median raphe regulates hippocampal ripple oscillation and memory consolidation

It has been suggested that hippocampal sharp-wave ripples (SWR) are important for memory consolidation. Here, the authors found that the activation of a non-serotoninergic subpopulation of median raphe neurons suppresses hippocampal sharp-wave ripples and impairs memory consolidation. These findings uncover a new brainstem influence on SWR and hippocampal memory function.