Localization of the gene for X-linked nephrogenic diabetes insipidus to Xq28

X-linked nephrogenic diabetes insipidus (NDI) was segregating in a large Indiana family. It was tested for linkage of the NDI gene to X-chromosome molecular markers. Maximum lod scores of 3.15 and 3.01 (θ=0) obtained for the molecular markers F8A (F8C) and DXS15 (DX13) respectively, indicate that the NDI gene is located in Xq28. A lod score of 3.61 (θ=0) was obtained with multipoint linkage analysis of F8A and DXS15.