Морфологическая оценка эффективности экспериментального моделирования L-NAME индуцированной эндотелиальной дисфункции

The article assess morphological changes in the vascular wall, and in particular in modeling in the endothelium of L-NAME induced endothelial dysfunction. It is shown that for 7 days of the experience, he starts a pilot injection N-nitro-L-arginine methyl ester (L-NAME), develop changes submicroscopic architectonic endothelial cells, resulting in endothelial dysfunction occurs. The leading element in the development of vascular diseases at the ultrastructural level is mitochondrial failure of endothelial cells. The selected method of L-NAME-induced endothelial pathology is characterized by high reproducibility and adequate results.