The progression in the role of regulatory B cells

Background B cells are typically characterized by the ability to produce antibodies and cytokines,also possess the ability to present agents.Regulatory B cells,as the B cell functionally distinct subset,performing both pathogenic and regulatory role in several murine models of autoimmunity and inflammation.Objective To discuss the most recently progress in the role of regulatory B cells.Content This paper sums up the characters of regulatory B cells,and the functions of regulatory B cells in the autoimmune diseases and tumor.Trend Currently,the exact identity and origin of the regulatory B cells remains elusive.The complex cellular network may differ for each pathology.Control of regulatory activity would be an alternative therapy for autoimmune diseases and tumors. Key words: B10;  Interleukin-10;  Autoimmunity;  Tumor