Activation of PPAR-δ in isolated rat skeletal muscle switches fuel preference from glucose to fatty acids

Aims/hypothesis GW501516, an agonist of peroxisome proliferator-activated receptor-δ (PPAR-δ), increases lipid combustion and exerts antidiabetic action in animals, effects which are attributed mainly to direct effects on skeletal muscle. We explored such actions further in isolated rat skeletal muscle.