Overexpression of lncRNA LINC01793 acts as a potential predictor for progression and poor prognosis of gastric cancer
2019
Objective. Accumulating evidence has
shown that differentially expressed long non-coding
RNA (lncRNA) is closely related to the development of
gastric cancer. This study aims to explore the role of
potential lncRNAs in the development of gastric cancer.
Methods. TCGA database of gastric cancer were
analyzed by bioinformatics. LINC01793 was
overexpressed in gastric cancer. Furthermore,
LINC01793 level in 21 pairs of gastric cancer and
paracancerous tissues were detected by qRT-PCR
(quantitative real-time polymerase chain reaction).
Prognostic analysis was performed to investigate the
predictive effect of LINC01793 on the prognosis of
patients with gastric cancer. GSEA analysis was
performed to investigate the possible biological
processes of LINC01793 involved in the development of
gastric cancer.
Results. LINC01793 was overexpressed in gastric
cancer tissues compared to paracancerous tissues.
Moreover, LINC01793 overexpression in gastric cancer
was closely related to patients with poor prognosis.
GSEA analysis found that LINC01793 was closely
related to apoptosis, cell cycle, invasion and metastasis
of gastric cancer cells.
Conclusions. Our study showed that overexpression
of LINC01793 indicates the poor prognosis of gastric
cancer patients. Therefore, LINC01793 may serve as a
target for the diagnosis and treatment of gastric cancer.
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