Tumor markers (pregnancy protein 1, placental-specific tissue protein 10, placental-specific tissue protein 12, α1-fetoprotein) in patients with bronchial carcinoma

The concentrations of pregnancy protein 1 (SP1), placental-specific tissue protein 10 (PP10), placental-specific tissue protein 12 (PP12) and a j-Fetoprotein (AFP) were analyzed in serum samples of 83 patients with bronchial carcinoma at stages II-IV. Protein levels were determined by means of single radial immunodiffusion, rocket immuno-electrophoresis, radioimmunoassay and enzyme- immunoassay. PP12 and AFP serum concentrations were significantly increased in the cancer group compared with the control group. PP12 (control group: x=54.08 μg/l; s=61.70; tumor group: x=122.52 μg/l; s=131.16); AFP (control group: x=3.05 μg/l; s=3.76; tumor group: x=8.29 μg/l; s= 17.75). SP1 was found in only 22 cases of the tumor group. PP10 (control group: x=2.25 μg/l; s=0.866; tumor group: x=2.503 μg/l; s=1.508). Given that at least two of the tested parameters were determined to be in the pathological range, the sensitivity amounted to 0.64 and the specificity to 0.92.