Enhancing the efficacy of cation-independent mannose 6-phosphate receptor inhibitors by intracellular delivery

Vipul Agarwal,Priyanka Toshniwal,Natalie E. Smith,Nicole M. Smith,Binbin Li,Tristan D. Clemons,Lindsay T. Byrne,Foteini Kakulas,Fiona M. Wood,Mark W. Fear,Ben Corry,K. Swaminathan Iyer

Enhancing the efficacy of cation-independent mannose 6-phosphate receptor inhibitors by intracellular delivery

2016

Vipul Agarwal
Priyanka Toshniwal
Natalie E. Smith
Nicole M. Smith
Binbin Li
Tristan D. Clemons
Lindsay T. Byrne
Foteini Kakulas
Fiona M. Wood
Mark W. Fear
Ben Corry
K. Swaminathan Iyer

Intracellular delivery of M6P/IGFII receptor inhibitors exhibits better efficacy than extracellular inhibitors to regulate TGFβ1 mediated upregulation of profibrotic marker, collagen I.

Keywords:

Intracellular
Cation-independent mannose-6 phosphate receptor
Extracellular
Organic chemistry
Chemistry
Downregulation and upregulation
Biochemistry
Receptor
collagen i

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