MİKROAKIŞKAN CİHAZ KULLANARAK POLİMERİK MİKROBALONCUK/NANOPARTİKÜLLERİN ÜRETİM VE KARAKTERİZASYONU

In recent years, polymeric micro/nanoparticles with different morphologies in biomedical applications have gained attention due to their potential in many applications such as controlled drug release. In this study, a T-junction microfluidic device was used to produce nanoparticles from polymer- coated microbubbles. The morphology and structure of microbubbles and nanoparticles were performed after the production process using optical microscopy, scanning electron microscopy (SEM), and Fourier- transform infrared spectroscopy (FT-IR). The diameter of the produced microbubbles and nanoparticles was 104 ± 91 μm and 116 ± 13 nm, respectively. The flow rate of the solution was found to have a significant effect on the diameter of the nanoparticles. These results can be very useful for many applications such as advanced therapeutic applications, cell transplantation in biomedical therapy, and the food industry.