Atrial natriuretic factor increases albumin extravasation in conscious rats.

Atrial natriuretic factor (ANF) lowers blood volume in intact and anephric experimental animals. The latter observation suggests extravasation of plasma at the level of the microcirculation. In view of the differential regional hemodynamic responses to ANF, the present study investigates possible regional differences in plasma extravasation measured as regional albumin clearances in skeletal muscle, lung, brain, ileum, and skin.