Protein composition in developing human brain myelin

Accumulation of protein and adenosine 2',3'-cyclic phosphohydrolase activity have been found to increase with age in myelin isolated from human subjects. Notable alterations in the quantitative distribution of myelin proteins separated by disc polyacrylamide gel electrophoresis were seen in development. Proteolipid protein was found in myelin before the appearance of basic encephalitogenic protein. A myelin-like fraction was also isolated from developing human brain. These chemical observations were correlated with ultrastructural changes in the isolated myelin during development.