012 — (CAM0047) Previous aerobic exercise program does not alter seizure susceptibility in adult female rats

postictal segments, the power in LG and HG frequencies decreased compared with baseline, while the power in HFOs increased in both analyzed regions. Delta postictal segment presented opposite activities in the mPFC and hippocampus, with sustained increase in the mPFC and no difference from baseline in the hippocampus. Discussion/conclusions: Using the present TLE model, we were able to induce late SRSs in an interval of 75 days, which had the EEG onset predominantly in the hippocampus and later spread to the cortex. Our results show electrographic changes in the preictal and postictal segments in all analyzed oscillations in themPFC and at high frequencies in the hippocampus. Changes in theta and HG frequency bands have been associated with cognitive deficits and psychiatric disorders, and an important relationship between changes in HFOs and the process of epileptogenesis has been suggested. The next steps will be the characterization of electrophysiological patterns in association with behavioral alterations generally found in the interictal period. This analysis will possibly provide relevant information about which energy band spectral in these conditions could predict SRSs and/or cognitive deficits.