Limonoids from Trichilia hirta

Abstract From the fruits and leaves of Trichilia hirta were isolated, besides sitosterol and sitostenone, two novel limonoids: methyl 11β-acetoxy-6-hydroxy-12α-(2-methylpropionyloxy)-3,7-dioxo-1,5,14,20,22-meliacapentaen-29-oate and methyl 11β-acetoxy-6,23-dihydroxy-12α-(2-methylpropionyloxy)-3,7,21-trioxo-1,5,14,20-meliacatetraen-29-oate. Three known protolimonoids, melianone, melianodiol and bourjotinolone A were also isolated. The limonoids and protolimonoids occurred only in the fruits, and sitostenone only in the leaves. Sitosterol occurred in both fruits and leaves. All structures were established from spectral data.