Исследование возможной острой, субхронической токсичности композиции на основе клеточных продуктов и безопасности её применения в эксперименте на животных

The aim of our study was to identify possible acute and subchronic toxicity, to establish the safety of the use of a composition based on cell products under experimental conditions in three types of laboratory animals, with different routes of administration. The studies were carried out on white mongrel mice weighing 19-21 g, white rats of the Wistar lineage weighing 190-240, rabbits of the Chinchilla breed with a mass of 2.8-3.6 kg of both sexes. The results of the conducted studies showed that the composition based on cell products in native form and as a 10% suspension does not cause acute and subchronic toxicity. The different degree of expression of motor activity and behavior, before and after administration of 0.4 ml of a 10% suspension of the test composition, became the main criterion for the separation of this population of females and males into subpopulations by the level of anxiety. The composition based on cell products does not cause a local irritant effect on mucous membranes and skin of rabbits. The test composition with subchronic application does not show sensitizing properties.