Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction
2014
Allosteric small-molecule inhibitors of the p53-induced oncogenic phosphatase Wip1 bind at a ‘flap’ subdomain near the catalytic site. Inhibitor GSK2830371 inhibits the phosphatase and oncogenic activities in cell lines and a xenograft tumor model.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
33
References
128
Citations
NaN
KQI