Intestinal absorption of enteric coating potassium sodium dehydroandroan drographolide succinate pellets in rat and in vivo pharmacokinetics study

Objective:To develop a method for determination the content of Potassium Sodium Dehydroandroan drographolide Succinate(PSDS) in rat intestinal contents and plasma and investigate the intestinal absorption of PSDS pellets in rat and in vivo pharmacokinetics of PSDS pellets.Methods:The content of PSDS in rat intestinal contents and plasma was determined by HPLC.In vivo pharmacokinetic properties and intestinal absorption of PSDS pellets in rat were investigated.Results:Two hours after administration,pellets were not found in the small intestine and large intestine,four hours after administration,the largest number of pellets were found in the small intestine and the concentration of PSDS was the highest in the intestinal contents(3593.13 μg).The characteristics of plasma concentration-time curve was consistent with a single compartment model.The main drug pharmacokinetic parameters were calculated.t1/2,Tmax,Cmax and AUC were 2.69 h,5 h,3.02 μg/mL and 6.42 μg·h/mL,respectively.Conclusion:PSDS has a good absorption in the rat small intestine and it is feasible to prepare PSDS enteric-coated pellets for oral administration.