One-Pot Route to β-Adrenergic Blockers via Enantioselective Organocatalyzed Epoxidation of Terminal Alkenes as a Key Step.
2015
A convenient two-step one-pot process leads to β-blockers (R)-pronethalol (IVa), nifenalol (IVb), and dichloroisoproterenol (IVc) from the corresponding aryl alkenes by combination of Shi-epoxidation and aminolysis.
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