A versatile synthesis of novel pan-PIM kinase inhibitors with initial SAR study

Abstract Herein, we describe the versatile synthesis of ( Z )-5-((2-aminopyrimidin-4-yl)methylene)thiazolidine-2,4-dione inhibitors ( 1 ) of the PIM family of kinases. This chemistry strategy was a key element in the multi-variable optimization program with the goal of identifying high quality leads for the development of a treatment for cancer.