RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway

The mechanisms by which viruses activate the NLRP3 inflammasome remain unclear. Zhou and colleagues show that RNA viruses initiate a RIP1-RIP3 complex that drives mitochondrial damage and activation of the NLRP3 inflammasome independently of necrosis.