Electrochemical determination of acetaminophen based on TiO2–graphene/poly(methyl red) composite film modified electrode

Abstract TiO 2 –graphene/poly(methyl red) composite film modified glassy carbon electrode (PMR/TiO 2 –GR/GCE) was first employed for the sensitive determination of acetaminophen (AC). The electrochemical behavior of AC was investigated by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The studies revealed that the oxidation of AC was facilitated at PMR/TiO 2 –GR/GCE. In 0.1 M phosphate buffer (pH 7.0). The peak current for AC was found to vary linearly with its concentration in the range of 2.5 × 10 − 7 –5 × 10 − 5  M with detection limit of 2.5 × 10 − 8 ( S / N  = 3). The modified electrode showed several advantages, such as simple preparation procedure, high sensitivity, low detection limit and good reproducibility. The proposed method was employed for the determination of AC in commercial pharmaceutical samples.