Synthesis of [1,2,4,5]tetrazino[6;,1':2,3]imidazo[4,5-c]isoquinolin-5-ones by microwave-assisted three-component reaction
2011
An efficient and original Ugi multicomponent reaction of aminopyridines and aminopyrimidines is reported. Starting from aminotetrazine 6 or 7, an isocyanide and an ortho-carboxybenzaldehyde, tetrazinoimidazoisoquinolinones were isolated, after few minutes of microwave irradiation, in good to excellent yields. The scope of this method was extended by using different isocyanides.
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